A new era in personalized imaging with quantitative PET/MR

When we first introduced Time-of-Flight (TOF) technology on a fully integrated PET/MR system, we said it would be revolutionary. We delivered on that promise and now we are taking it even further.

Introducing SIGNA™ PET/MR with QuantWorks. Built with pioneering TOF and integrated with a 3.0T MR, its impressive quantitative accuracy and high count rate combined with innovative Q.Clear reconstruction delivers 2x improvement in image quality. In addition, SIGNA PET/MR with QuantWorks includes a comprehensive suite of applications and flexible research tools to pursue ideas that could influence the future of medicine.

Light Tight RF Shield with copper coating



Lutetium Based Scintillator (LBS) crystal array with light and Enhanced Spectral Reflectors (ESR)



SiPM - Silicon PhotoMultiplier with circuit boards/ASICS

Thermal coupling gasket


Aluminum mounting plate



The full diagnostic potential of high sensitivity and TOF

SIGNA PET/MR with QuantWorks is built with proprietary Silicon PhotoMultiplier (SiPM) detectors and the exceptional sensitivity of 25 mm deep Lutetium-based crystals. The result is a fully integrated PET/MR with high sensitivity and TOF capability.

In addition, our innovative Q.Clear reconstruction leverages the excellent signal-to-noise ratio (SNR) enabled by TOF. And our Zero Echo Time (ZTE) MR substitutes X-ray based attenuation correction with ionizing-radiation-free MR in the head. This combination of improvements to image quality and quantitation accuracy enables you to embrace the full potential of PET/MR.



Trust with consistently accurate results.

When you can trust the accuracy of each result, quantitation takes on a whole new meaning.

SIGNA PET/MR with QuantWorks combines the clarity of our TOF technology with the consistency of Q.Clear. Using innovative reconstruction, Q.Clear incorporates prior knowledge about image quality into reconstructed images to decrease noise while providing quantitation accuracy and significantly improving image quality. In addition, SIGNA PET/MR with QuantWorks includes the most comprehensive motion correction package in the industry to reduce the effects of involuntary and physiological motion. And our ZTE MR, a true ZTE imaging technique, can ‘see’ bone for an ionizing-radiation-free attenuation correction method with MR.

This exclusive combination of TOF technology and Q.Clear provides you with another tool you can rely on to confidently guide the decisions that impact patient care.

Reduced noise


Q.Clear incorporates prior knowledge about image quality into the reconstructed image to decrease noise while providing quantitation accuracy and significantly improved image quality.



ZTE MR replaces the X-ray based gold standard for attenuation correction with this accurate, personalized ionizing-radiation-free MR technique. Based on the high stability of SIGNA PET/MR with QuantWorks’ hardware, our ZTE MR is more reliable and faster than Ultra Short Echo (UTE) and improves image quality.


Comprehensive Motion Correction Solutions

Solutions to reduce involuntary and physiological movement with an extensive selection of motion correction applications for PET and MR, including PROPELLER, PROMO and Pencil Beam Navigator.


The new standard is extraordinary

Our new SIGNA™Works applications portfolio redefines productivity and improves security across the breadth of our core imaging techniques. SIGNA PET/MR with QuantWorks comes preloaded with the standard applications portfolio of SIGNA™Works as a fully integrated package. This extensive library of high quality and efficient imaging techniques enables you to achieve the outcomes you desire across your entire practice.

SIGNA™Works’ advanced applications include HyperWorks, ViosWorks, ImageWorks and SilentWorks, which further advance diagnostics and accelerate throughput while simultaneously improving patient outcomes and your ROI.

Not only is SIGNA™Works upgradeable, it can be further customized, so you have the flexibility to add applications to suit the needs of your practice.


Phenomenal exams to meet your clinical needs

New avenues of discovery

Explore all that PET/MR is capable of by using SIGNA PET/MR with QuantWorks’ extensive offering of research tools.

SIGNA PET/MR with QuantWorks has the tools you need to discover disease-specific tracers and develop new protocols. You can use PET/MR simultaneously with MR multinuclear spectroscopy as an in-vivo laboratory to study fast biochemical processes. In addition, PET ToolBox and Orchestra Software Development Kit give you offline access to our image reconstruction environments for PET and MR making it faster and easier to work on your own reconstruction ideas.

SIGNA PET/MR with QuantWorks provides the tools you need to push the boundaries of its innovative technology.

Orchestra Software Development Kit

Orchestra Software Development Kit

Directly access SIGNA PET/MR with QuantWorks’ image reconstruction environment offline and work with raw image data without having to be at the scanner.

PET ToolBox

PET ToolBox

Develop novel PET imaging techniques using our software tools to access the PET image reconstruction environment.

Organ-Specific Applications

Organ-Specific Applications

Segment, measure and compare volumetric brain images to normal brain images with NeuroQuant MR for objective support when identifying neurodegenerative diseases.

Analyze brain studies with beta amyloid and FDG tracers and compare them to FDG normals with CortexID multimodality package.

Get a comprehensive cardiovascular assessment with ViosWorks in one free-breathing, eight-minute scan that provides quantitative 3D information for cardiac anatomy, function and flow.

In-vivo Laboratory
In-vivo Laboratory
In-vivo Laboratory


In-vivo Laboratory

Images acquired separately courtesy of UCSF and University Hospital Zurich

Simultaneously use PET/MR with MR multinuclear spectroscopy as an in-vivo laboratory to study fast biochemical processes.

Supporting Materials

  • MotionFree Brain is 510(k) pending with the US FDA. Not yet CE marked. Not available for sale.